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KMID : 0928320130130010001
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Korean Journal of Health Promotion and Disease Prevention
2013 Volume.13 No. 1 p.1 ~ p.7
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The Relationship Between Serum Total Bilirubin and Framingham Risk Score in Healthy Korean Men
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Chun Hye-Jin
Lee Sang-Wha
Choi Yu-Kyung
Lee Hong-Soo
Shim Kyung-Won
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Abstract
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Background: Serum total bilirubin has been considered a harmful substance inducing oxidative reaction; but recently, there have been reports of it possessing antioxidative, anti-inflammatory and protective features against cardiovascular diseases. The purpose of this study was to investigate the relationship between total bilirubin and the Framingham risk score.
Methods: This study involved 3,414 healthy Korean men who underwent a medical check-up in a health promotion center in 2008. We calculated the Framingham risk score using age, smoking status, systolic blood pressure, total cholesterol and high-density lipoprotein cholesterol.
’Results: The mean age of the participants was 44.9±8.8 years. The log transformed serum total bilirubin level and the Framingham risk score had a negative linear relationship in a simple linear regression analysis (R2: 0.018, P<0.001). In a multivariable analysis model, as well, the log transformed serum total bilirubin level and the Framingham risk score had a negative linear relationship (R2: 0.384, P<0.001).
Conclusions: Our study showed a statistically significant negative relationship between total bilirubin and the Framingham risk score. Total bilirubin had a stronger relationship with the Framingham risk score than other standard cardiovascular risk factors except smoking, and thus may be useful in predicting cardiovascular risk in the outpatient clinic.
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KEYWORD
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Total bilirubin, Framingham risk score, Cardiovascular disease
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